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    <ns6:brs_depositor xml:lang="en">Takashi ONODERA</ns6:brs_depositor>
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    <ns1:colonyMaintenance xml:lang="ja">特になし</ns1:colonyMaintenance>
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    <rdfs:label xml:lang="en">B6.129P2-Prnp&lt;tm1Ito&gt;/Rbrc</rdfs:label>
    <rdfs:label>B6.129P2-Prnp&lt;tm1Ito&gt;/Rbrc</rdfs:label>
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    <ns6:brs_depositorOrganization xml:lang="en">Univ. Tokyo</ns6:brs_depositorOrganization>
    <ns4:application>Mouse Models for Human Disease</ns4:application>
    <ns4:termsAndConditions xml:lang="ja">条件を付加する。利用者は事前に寄託者の提供承諾書を得る。&lt;br&gt;研究成果の公表にあたって寄託者の指定する文献を引用する。Nature. 1999 Jul 15;400(6741):225-6.</ns4:termsAndConditions>
    <ns1:strainDevelopment xml:lang="en">Developed by Drs. Takashi Yokoyama, National Institute of Animal Health and Shigeyoshi Itohara, RIKEN BSI in 2001. C57BL/6J background.</ns1:strainDevelopment>
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    <dc:description xml:lang="en">PrP, the prion protein, plays a central role in the pathogenesis of transmissible neurodegenerative disorders such as scrapie or BSE. Homozygous mutant mice show the absence of cellular isoform of prion protein. Aged homozygous mice exhibit tremor and ataxia.</dc:description>
    <ns4:termsAndConditions xml:lang="en">The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature. 1999 Jul 15;400(6741):225-6.</ns4:termsAndConditions>
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    <ns4:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Approval form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns4:addinfo>
    <ns1:colonyMaintenance xml:lang="en">Sibling Mating (Homozygote x Homozygote)Aged mice exhibit tremor and ataxia.</ns1:colonyMaintenance>
    <ns1:colonyMaintenance xml:lang="en">Sibling Mating (Homozygote x Homozygote) Aged mice exhibit tremor and ataxia.</ns1:colonyMaintenance>
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    <dc:description xml:lang="ja">加齢に伴う後肢麻痺.</dc:description>
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    <ns6:brs_depositor xml:lang="ja">小野寺　節</ns6:brs_depositor>
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    <ns1:strainDevelopment xml:lang="en">Developed by Drs. Takashi Yokoyama, National Institute of Animal Health and Shigeyoshi Itohara, RIKEN BSI in 2001.C57BL/6J background.</ns1:strainDevelopment>
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